ChloraPrep Patient Preoperative Skin Preparation

Superior infection prevention starts with ChloraPrep

ChloraPrep is a rapid-acting, persistent, and broad-spectrum antiseptic for a range of minor and major medical procedures. The 2% Chlorhexidine Gluconate/70% Isopropyl Alcohol formulation acts fast on a broad spectrum of bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), and keeps fighting bacteria for at least 48 hours.^1,2 Together, the formulation and applicator provide a proven system that supports infection control guidelines for helping to reduce the incidence of BSIs and SSIs.

New evidence supporting the use of ChloraPrep

Efficacy of Surgical Preparation Solutions in Shoulder Surgery

ChloraPrep is more effective than DuraPrep and povidone-iodine at eliminating overall bacteria from the shoulder region.⁷

Translating Evidence into Practice to Prevent Central Venous Catheter-associated Bloodstream Infections

Wishard Memorial Hospital calculated an annual savings of $348,000 when 2% chlorhexidine gluconate and 70% isopropyl alcohol skin antisepsis was incorporated into a CVC kit.⁸

The ChloraPrep Advantage

ChloraPrep is a superior broad-spectrum antimicrobial compared to traditional iodophors.

Rapid acting: The 70% isopropyl alcohol in ChloraPrep rapidly kills microorganisms versus free iodine, which requires two minutes to begin antimicrobial activity³
Persistent: ChloraPrep maintains antimicrobial activity for at least 48 hours^1,2 compared to two hours for free iodine³
Broad spectrum: ChloraPrep antimicrobial activity is effective against microorganisms including gram-positive and gram-negative bacteria, Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant Enterococci (VRE), Clostridium difficile, Acineobacter, and most viruses and fungi^2,3,4
Active in protein-rich biomaterials: Remains active in the presence of blood, serum and other protein-rich biomaterials^4,5 unlike traditional iodophors, which are neutralized⁶
Low irritation: CHG demonstrates low incidence of irritation⁴

Learn more about the ChloraPrep advantage

1 Garcia R, Mulberry G, Brady A, Hibbard JS. Comparison of ChloraPrep and Betadine as preoperative skin preparation antiseptics. Poster presented at: 40th Annual Meeting of the Infectious Disease Society of America; October 25, 2002.

2 Data on file, CareFusion Corporation.

3 Crosby CT, Mares AK. Skin antisepsis: past, present and future. J Vasc Access Devices. 2001;6(1):26-31.

4 Denton GW. Chlorhexidine. In: Block SS. Disinfection, Sterilization, and Preservation. 5th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2001:321-336.

5 Chaiyakunapruk N, Veenstra DL, Lipsky BA, Saint S. Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis. An intern Med. 2002;136:792-801.

6 Gottardi W. Iodine and Iodine Compounds. In: Block SS. Disinfection, Sterilization, and Preservation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2001:159-183.

7 Saltzman MD, Nuber GW, Gryzlo SM, Marecek GS, Koh JL. Efficacy of surgical preparation solutions in shoulder surgery. J Bone Joint Surg Am. 2009;91 A(8):1949–1953.

8 Young EM, Commiskey ML, Wilson SJ. Translating evidence into practice to prevent central venous catheter-associated bloodstream infections: a systems-based intervention. Am J Infect Control. 2006;34(8):503-506.

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Learn more about the source of infection – the patient's own skin.

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